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Natural Product Research
Formerly Natural Product Letters
Volume 30, 2016 - Issue 23
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Research Articles

Two new polyhydroxylated triterpenoids from Salvia urmiensis and their cytotoxic activity

Mahdi Moridi FarimaniDepartment of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Tehran, IranCorrespondence[email protected]
&
Mahdi Abbas-MohammadiDepartment of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Tehran, Iran
Pages 2648-2654 | Received 20 Oct 2015, Accepted 17 Dec 2015, Published online: 01 Feb 2016
 
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Abstract

Two new polyhydroxylated triterpenoids were isolated from the acetone extract of the aerial parts of Salvia urmiensis Bunge. Their structures were elucidated by 1D and 2D NMR and HR-ESI-MS analyses as olean-12-ene-1β,3β,11α,22α-tetraol (1) and urs-12-ene-1β,3β,11β,22α-tetraol (2). The effect of these compounds on cell viability of MCF-7 cells was investigated by the MTT assay. Compounds 1 and 2 showed weak cytotoxicity with IC50 values of 110.23 ± 0.12 and 88.35 ± 0.09 μM, respectively.

Graphical abstract

Acknowledgements

Financial support by the Shahid Beheshti University Research Council is gratefully acknowledged. All spectra were performed at the Department of Pharmaceutical Sciences, Division of Pharmaceutical Biology, University of Basel. The kind assistance of Prof M. Hamburger, Dr S.N. Ebrahimi, and all other staff is gratefully appreciated.

Disclosure statement

No potential conflict of interest was reported by the authors.

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