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Natural Product Research
Formerly Natural Product Letters
Volume 30, 2016 - Issue 24
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Research Articles

Callyptide A, a new cytotoxic peptide from the Red Sea marine sponge Callyspongia species

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Pages 2783-2790 | Received 23 Nov 2015, Accepted 02 Feb 2016, Published online: 07 Mar 2016
 

Abstract

In the course of our continuing efforts to allocate bioactive secondary metabolites from Red Sea marine invertebrates, we have investigated the sponge Callyspongia species. The cytotoxic dichloromethane fraction of the methanolic extract of the sponge afforded a new cytotoxic peptide named callyptide A (1). Its structure was determined by extensive 1D and 2D NMR (COSY, HSQC and HMBC) studies and high-resolution mass spectral determination. The configuration of the amino acids was determined by Marfey’s analysis. Callyptide A was found to exhibit growth inhibitory activity when tested against different cancer cell lines.

Acknowledgments

This project was funded by the Deanship of Scientific Research (DSR), King Abdulaziz University, Jeddah, under grant no. (40 / 141 / 1434). The authors, therefore, acknowledge with thanks DSR technical and financial support. We would like to thank Dr. Rob van Soest for the taxonomic identification of the sponge material.

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