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Natural Product Research
Formerly Natural Product Letters
Volume 31, 2017 - Issue 12
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Research Articles

Three new phenylpropanoids from Lavandula angustifolia and their bioactivities

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Pages 1351-1357 | Received 18 Jul 2016, Accepted 17 Sep 2016, Published online: 21 Oct 2016
 

Abstract

Three new phenylpropanoids, 3-(3,4-dimethoxy-5-methylphenyl)-3-oxopropyl acetate (1), 3-hydroxy-1-(3,4-dimethoxy-5-methylphenyl)propan-1-one (2), and 3-hydroxy-1-(4-methylbenzo[d][1,3]dioxol-6-yl) propan-1-one (3), together with three known phenylpropanoids (46) were isolated from the whole plant of Lavandula angustifolia. Their structures were determined by means of HRESIMS and extensive 1D and 2D NMR spectroscopic studies. Compounds 16 were tested for their anti-tobacoo mosaic virus (TMV) activities and cytotoxicity activities. The results revealed that compounds 13 showed high anti-TMV activity with inhibition rate of 35.2, 38.4 and 33.9%. These rates are higher than that of positive control. The other compounds also showed potential anti-TMV activities with inhibition rates in the range of 26.8–28.9%, respectively. Compounds 16 also showed weak inhibitory activities against some tested human tumour cell lines with IC50 values in the range of 3.8–8.8 μM.

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