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Natural Product Research
Formerly Natural Product Letters
Volume 31, 2017 - Issue 12
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Research Articles

Lignans from the shed trunk barks of the critically endangered plant Abies beshanzuensis and their anti-neuroinflammatory activities

, , , , &
Pages 1358-1364 | Received 22 Jul 2016, Accepted 17 Sep 2016, Published online: 23 Oct 2016
 

Abstract

During a further and comprehensive phytochemical investigation on the shed trunk barks of the critically endangered plant Abies beshanzuensis, one new (1) and ten known (211) lignans with diverse structures were isolated. On the basis of spectroscopic methods, the new structure was established to be (7S,8R,8′R)-4′-methoxyl-α-conidendrin (1). Among the isolated lignans, (−)-matairesinol (5) and (−)-arctigenin (6) showed significant anti-neuroinflammatory activities by inhibiting the overproduction of nitric oxide in lipopolysaccharide-stimulated murine BV-2 microglial cells, with IC50 values of 11.5 and 19.0 μM, respectively.

Acknowledgements

The authors are grateful to Lishui Institute of Agricultural Science (Zhejiang Province, China) for the assistance of the plant collection.

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