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Natural Product Research
Formerly Natural Product Letters
Volume 31, 2017 - Issue 12
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Short Communication

Chemical composition and evaluation of prolyl oligopeptidase and acetylcholinesterase inhibitory activities of Leonurus Sibiricus L. from Brazil

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Pages 1459-1463 | Received 22 Jul 2016, Accepted 18 Oct 2016, Published online: 11 Nov 2016
 

Abstract

Chemical investigation of the aerial parts of Leonurus sibiricus L. used in Brazilian folk medicine led to the identification of the following constituents: the labdane-type diterpenoid leojaponin, the phytosterols β-sitosterol and β-sitosterol glucoside and the alkaloid leonurine. The crude extracts obtained from methanol and methanol/1% HCl and pure compounds isolated from L. sibirius were investigated as acetylcholinesterase (AChE) and prolyl oligopeptidase (POP) inhibitors. Extracts obtained by maceration were active against POP (53–58%), but showed weak activity against AChE. The isolated leojaponin and leonurine were evaluated as POP inhibitors.

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