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Natural Product Research
Formerly Natural Product Letters
Volume 31, 2017 - Issue 12
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Research Articles

Metabolites from the co-culture of nigranoic acid and Umbelopsis dimorpha SWUKD3.1410, an endophytic fungus from Kadsura angustifolia

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Pages 1414-1421 | Received 10 Apr 2016, Accepted 23 Oct 2016, Published online: 10 Nov 2016
 

Abstract

The ability of the endophytic fungus Umbelopsis dimorpha SWUKD3.1410 to transform the triterpene nigranoic acid (3, 4-secocycloarta-4(28), 24-(Z)-diene-3, 26-dioic acid; 1) was investigated. Co-culture of nigranoic acid with U. dimorpha SWUKD3.1410 yielded six major products, including a new triterpene (2) and 5 known compounds (37). Their structures were identified by the extensive 1D, 2D NMR and HR-ESI-MS Data analysis, and by comparison with those reported data. Among them, 24 were transformed from nigranoic acid (1), while 57 were derived from the culture medium stimulated by the substrate. On the basis of the structures of 24, it was proposed that the transformative process probably involved isomerase and hydroxylase, in which the former was rare in fungi. Additionally, all the compounds (17) were evaluated for their cytotoxic activity. As a result, compounds 1, 35 exhibited weak cytotoxicity against the tested cell lines, while others showed no cytotoxicity.

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