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Natural Product Research
Formerly Natural Product Letters
Volume 31, 2017 - Issue 9
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Research Articles

Two new coumarins from the bark of Streblus indicus (Bur.) Corner

Ruijie HeState Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University, Guilin, P.R. China;Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization, Guangxi Institute of Botany, Guilin, P.R. China
,
Shengping DengState Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University, Guilin, P.R. China
,
Hui NieState Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University, Guilin, P.R. China
,
Yan HuangGuangxi Key Laboratory of Tradtional Chinese Medicine Quality Stardands, Guangxi Insitute of Chinese Medicine & Pharmaceutical Science, Nanning, P.R. China
,
Buming LiuGuangxi Key Laboratory of Tradtional Chinese Medicine Quality Stardands, Guangxi Insitute of Chinese Medicine & Pharmaceutical Science, Nanning, P.R. China
,
Ruiyun YangState Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University, Guilin, P.R. China
,
Shuai HuangState Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University, Guilin, P.R. China
,
Dexiong ZhouState Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University, Guilin, P.R. China
,
Huangcan ChenState Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University, Guilin, P.R. China
,
Jun LiState Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University, Guilin, P.R. China;Guangxi Key Laboratory of Tradtional Chinese Medicine Quality Stardands, Guangxi Insitute of Chinese Medicine & Pharmaceutical Science, Nanning, P.R. ChinaCorrespondence[email protected]
&
Yanjun ZhangState Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University, Guilin, P.R. ChinaCorrespondence[email protected]
[email protected]
 show all
Pages 1052-1058 | Received 25 Jul 2016, Accepted 20 Nov 2016, Published online: 26 Dec 2016
 
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Abstract

Two new coumarins 7-O-(6-O-(5-O-3,4,5-tri-methoxycinnamate-β-d-apiofuranosyl-β-d-glucopyranosyl)-6-methoxy coumarin (1) and 7-O-(6-O-(4-(2-hydroxy-1-hydroxymethyl-ethoxy)-3-methoxy-cinnamyl)-β-d-glucopyranosyl)-6-methoxy coumarin (2), along with 10 known metabolites, were isolated from the bark of Streblus indicus, their structures were identified by comparison of experimental and published spectroscopic data. (S)-marmesinin (6) and scoparone (7) exhibited moderate antimicrobial activity in vitro against Staphylococcus aureus strain with the MIC values of 62.5 and 125.0 μg/mL, respectively. Betulinic acid showed inhibitory activity in vitro against MCF-7 cell with IC50 value of 9.5 ± 0.1 μM.

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Related Research Data

Two new coumarins from the bark of Streblus indicus (Bur.) Corner
Source: Figshare
Two new coumarins from the bark of Streblus indicus (Bur.) Corner
Source: Figshare

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