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Abstract
A new flavonoid, crotakanda (1), and seven known compounds including a flavonoid, four isoflavonoids, a pterocarpan and a cinnamaldehyde were isolated from the stems and roots of Crotalaria bracteata. Their structures were elucidated by a combination of spectroscopic methods. Compound 2 showed cytotoxicity against MCF-7 with an IC50 value of 79.90 μM whereas 2 and 4 exhibited cytotoxicity against the NCI-H187 cell line with IC50 values of 71.57 and 95.47 μM, respectively.
Acknowledgements
We thank Khon Kaen University and the Center of Excellence for Innovation in Chemistry (PERCH-CIC), Office of the Higher Education Commission, Ministry of Education for partial support. The Bioassay Laboratory of the National Center for Genetic Engineering and Biotechnology, Pathumthani, Thailand, is gratefully acknowledged for biological activity assays.
Notes
In remembrance of His Majesty King Bhumibol Adulyadej (1927–2016).
