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Abstract
Eight compounds were isolated from the seeds of Holarrhena antidysenterica Wall.ex A.DC. On the basis of physico-chemical properties and spectroscopic data, holarrhenanan (1) was identified as a new compound, compounds 2–3 were isolated from H. antidysenterica for the first time, and five known compounds were also obtained. Inhibitory effects of some compounds and extracts to the intestinal peristalsis were evaluated. Results showed that the extracts and compounds 4, 6 exhibited remarkable inhibitory effects with tension inhibition rate of 32.77, 32.77% and amplitude inhibition rate of 59.51, 55.98%, respectively on the vitro rabbit intestinal peristalsis.
Acknowledgements
We are indebted to professor Li Wen of Shenyang Pharmaceutical University for helping to run the 1D and 2D NMR spectra.
Disclosure statement
No potential conflict of interest was reported by the authors.
Funding
This work was supported by the Student Innovation Training Program of Shenyang Pharmaceutical University.
Geolocation
Dried seeds of H. antidysenterica were cultivated in Xinjiang Province in China.
Supplemental data
Supplemental data for this article can be accessed at http://dx.doi.org/10.1080/14786419.2017.1315574.
Supplementary material
Supplementary materials relating to this paper are available online (1D NMR, 2D NMR, HR-ESI-MS and IR spectra).
