Minor compounds of the high purity salvianolic acid B freeze-dried powder from Salvia miltiorrhiza and antibacterial activity assessment

Abstract

The study explored the isolation and characterisation of three compounds of high purity salvianolic acid B freeze-dried powder extracted from Salvia miltiorrhiza Bunge. A new salvianolic acid, salvianolic acid V (2) together with two known compounds (3–4) was identified. The antibacterial activity tests showed that compound 2 combined with clinical antibiotics such as Levofloxacin or Colistin sulphate together exhibited potent effects against MRSA or Acinetobacter baumanii. This report has considerably extended our knowledge about the diversity and bioactivity of caffeic acid derivatives from S. miltiorrhiza.

Keywords:

• Salvianolic acid
• Salvia miltiorrhiza
• new compound
• antibacterial agents
• potentiation
• MRSA
• Acinetobacter baumanii

Acknowledgement

The authors are grateful to the Yue Li and Heng-shuai Wang for measurements of NMR, HR-ESI-MS spectra at Shanghai Institute of Pharmaceutical Industry (Shanghai, China)