Lamesticumin G, a new α-glucosidase inhibitor from the fruit peels of Lansium parasiticum

Abstract

A novel onoceranoid triterpene, named lamesticumin G (1) along with four known compounds (2–5) were isolated from the ethyl acetate extract of the fruit peels of Lansium parasiticum. The structure of lamesticumin G (1) was fully characterised using spectroscopic data. Lamesticumin G (1) inhibited α-glucosidase (maltase) with IC₅₀ value of 2.27 mM, while 2–5 showed no inhibition.

Keywords:

• Lamesticumin G
• Lansium parasiticum
• Meliaceae
• triterpenoid
• α-glucosidase
• onoceranoid
• diabetes

Acknowledgements

TP is grateful to Nantaporn Surachaitanawat and Dr Rico Ramadhan for technical assistances. WW gratefully acknowledges the graduate School of Chulalongkorn University for a Postdoctoral Fellowship (Ratchadaphiseksomphot Endowment Fund).