Chemical constituents from Curcuma longa L. and their inhibitory effects of nitric oxide production

Ting YuanKey Laboratory of Structure-Based Drug Design & Discovery, School of Traditional Chinese Materia Medica, Ministry of Education, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China

Cuiyun ZhangKey Laboratory of Structure-Based Drug Design & Discovery, School of Traditional Chinese Materia Medica, Ministry of Education, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China

Chongyue QiuKey Laboratory of Structure-Based Drug Design & Discovery, School of Traditional Chinese Materia Medica, Ministry of Education, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China

Guiyang XiaKey Laboratory of Structure-Based Drug Design & Discovery, School of Traditional Chinese Materia Medica, Ministry of Education, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China

Fei WangKey Laboratory of Structure-Based Drug Design & Discovery, School of Traditional Chinese Materia Medica, Ministry of Education, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China

Bin LinKey Laboratory of Structure-Based Drug Design & Discovery, School of Pharmaceutical Engineering, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China

Hua LiKey Laboratory of Structure-Based Drug Design & Discovery, School of Traditional Chinese Materia Medica, Ministry of Education, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China;Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of ChinaCorrespondence[email protected]

Lixia ChenKey Laboratory of Structure-Based Drug Design & Discovery, School of Traditional Chinese Materia Medica, Ministry of Education, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, People’s Republic of ChinaCorrespondence[email protected]

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Abstract

A new bisabolane-type sesquiterpenoid, turmerone Q (1), along with six known compounds (2–7), were isolated from the rhizomes of Curcuma longa L. The structural elucidation of the new compound was conducted using ¹H NMR, ¹³C NMR, HSQC, HMBC and NOESY spectroscopic analyses. The absolute configuration of 1 was elucidated by comparison of the experimental and calculated ECD spectra. The anti-inflammatory effects of 1–7 were evaluated through lipopolysaccharide-induced nitric oxide (NO) production in RAW 264.7 macrophages assays, and compounds 6 and 7 showed potent inhibitory activity against NO production.

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Chemical constituents from Curcuma longa L. and their inhibitory effects of nitric oxide production

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Chemical constituents from Curcuma longa L. and their inhibitory effects of nitric oxide production

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