Chemical analysis and antiviral activity evaluation of Baccharis anomala

Caroline Rita VenturiFaculdade de Farmácia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil

Srgio Augusto De Loreto BordignonPrograma de Pós-graduação em Avaliação de Impactos Ambientais, Centro Universitário La Salle, Canoas, Brazil

Paulo Michel RoeheInstituto de Ciências Básicas da Saúde (ICBS), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, BrazilCorrespondence[email protected]

Jarbas Alves MontanhaFaculdade de Farmácia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, BrazilCorrespondence[email protected]

Samuel Paulo CibulskiInstituto de Ciências Básicas da Saúde (ICBS), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil

Grace GosmannFaculdade de Farmácia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil

Abstract

The chemical composition and antiviral activity of aqueous extract from Baccharis anomala was studied by bioactivity-guided fractionation. Ethanol precipitation and fractionation by molecular permeation allowed the separation of the anti-herpes simplex virus 1 (HSV-1) active fraction from aqueous extract (Fraction B). Natural Product Reagent A, FeCl₃ and thin-layer chromatography indicated the presence of phenolic compounds in the aqueous extract. Fraction B showed pronounced antiviral activity when tested with HSV-1 strains VR733/ATCC and Acyclovir-resistant 29-R, displaying virucidal but not virustatic activity.

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Chemical analysis and antiviral activity evaluation of Baccharis anomala

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