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Natural Product Research
Formerly Natural Product Letters
Volume 33, 2019 - Issue 5
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Research Articles

Bioactive isoquinoline alkaloids from Cissampelos pareiraFootnote

, , , , &
Pages 622-627 | Received 13 Jul 2017, Accepted 21 Oct 2017, Published online: 10 Nov 2017
 

Abstract

The phytochemical and biological investigation of Cissampelos pareira leads to the isolation of one new isoquinoline alkaloid (7) along with six known isoquinoline alkaloids, namely, magnoflorine (1), magnocurarine (2), cissamine (3), curine (4), hayatinine (5) and cycleanine (6). Magnoflorine (1) and magnocurarine (2) were isolated for the first time from C. pareira. A new, rapid, simple and sensitive UPLC method was developed for simultaneous quantification of five pure compounds (15). Seasonal variation study revealed higher content of these compounds during the rainy season. The chloroform (CPCF) and n-butanol (CPBF) fractions showed cytotoxic efficacy against KB cells. Among pure compounds, hayatinine (5) was found to be most active against KB and A549, while, cycleanine (6) against KB cells.

Acknowledgements

Authors are grateful to the Director of the institute for providing the necessary facilities. We are also thankful to Mr Pawan Kumar for his technical support.

Notes

† CSIR-IHBT Communication No. 3831.

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