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Natural Product Research
Formerly Natural Product Letters
Volume 33, 2019 - Issue 5
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Research Articles

Cytotoxic triterpene saponins from the mangrove Aegiceras corniculatum

, , , , , , , , & show all
Pages 628-634 | Received 06 Sep 2017, Accepted 17 Oct 2017, Published online: 16 Nov 2017
 

Abstract

Using various chromatographic separations, sixteen compounds, including one new triterpene saponin named aegicoroside A (1), were isolated from the leaves of the Vietnamese mangrove Aegiceras corniculatum. Their structures were determined by spectroscopic methods such as 1D and 2D NMR and HR-ESI-MS. The cytotoxic activities of the isolated compounds against MCF7 (breast), HCT116 (colon), B16F10 (melanoma), and A549 (adenocarcinoma) cancer cell lines were also evaluated. Strong cytotoxicity was observed for sakurasosaponin (2) against all four cancer cell lines and for sakurasosaponin methyl ester (3) against MCF7, A549, and HCT116 cell lines with IC50 values ranging from 2.89 ± 0.02 to 9.86 ± 0.21 μM.

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