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Natural Product Research
Formerly Natural Product Letters
Volume 33, 2019 - Issue 5
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Research Articles

Anti-inflammatory constituents from Psychotria prainii H. Lév

Phi Hung TranDepartment of Phytochemistry, National Institute of Medicinal Materials, Hanoi, Vietnam;Department of Pharmacy, National Hospital of Traditional Medicine, Hanoi, Vietnam
,
Viet Dung LeDepartment of Phytochemistry, National Institute of Medicinal Materials, Hanoi, VietnamCorrespondence[email protected]
,
Thi Ha DoDepartment of Phytochemistry, National Institute of Medicinal Materials, Hanoi, Vietnam
,
Thi Luyen NguyenInstitute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam;Center for Research and Technology Transfer, VAST, Hanoi, Vietnam
,
Phuong Thao NguyenInstitute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam
,
Trong Thong NguyenDepartment of Pharmacology, Hanoi Medical University, Hanoi, Vietnam
&
Tien Dat NguyenCenter for Research and Technology Transfer, VAST, Hanoi, VietnamCorrespondence[email protected]
 show all
Pages 695-700 | Received 11 Apr 2017, Accepted 10 Nov 2017, Published online: 06 Dec 2017
 
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Abstract

One new and three known compounds were isolated from the ethanol extract of Psychotria prainii aerial parts. By means of spectroscopic methods, their structures were elucidated to be deacetylasperulosidic acid 6-ethyl ether (1), asperulosidic acid (2), asperuloside (3) and obtucarbamates C (4). The isolated compounds were evaluated for their inhibitory effect on NO production in LPS-stimulated RAW264.7 cells. Among them, compounds 2 and 4 exhibited strong effect with the IC50 values of 5.75 ± 0.85 and 6.92 ± 0.43 μM, respectively. This is the first report for the chemical composition and biological activity of P. prainii.

Acknowledgement

We thank Dr. Marie-Lise Bourguet-Kondracki (Musée National d’Histoire Naturelle, Paris, France) for providing HRMS data.

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