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Natural Product Research
Formerly Natural Product Letters
Volume 33, 2019 - Issue 5
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Short Communication

Study on the activity and mechanism of skimmianine against human non-small cell lung cancer

Yangsong ZuoDepartment of Respiratory Medicine, Lianshui County People’s Hospital, Huaian, P. R. China
,
Juan PuDepartment of Radiotherapy, Lianshui County People’s Hospital, Huaian, P. R. ChinaCorrespondence[email protected]
,
Guiming ChenDepartment of Thoracic Surgery, Lianshui County People’s Hospital, Huaian, P. R. China
,
Wenyi ShenDepartment of Respiration, Lianshui County People’s Hospital, Huaian, P. R. China
&
Baoran WangDepartment of Oncology, Lianshui County People’s Hospital, Huaian, P. R. China
Pages 759-762 | Received 14 Sep 2017, Accepted 11 Nov 2017, Published online: 29 Nov 2017
 
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Abstract

The present research was to investigate the effects of skimmianine (SK) in four non-small cell lung cancer (NSCLC) cells. We found that SK can significantly inhibit the growth of NSCLC cells and markedly induce apoptosis in NSCLC cells. The effects of growth inhibition and apoptosis induction were in a concentration–response relationship and caspase-dependent manner.

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