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Natural Product Research
Formerly Natural Product Letters
Volume 33, 2019 - Issue 6
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Research Articles

A bioactive new protostane-type triterpenoid from Alisma plantago-aquatica subsp. orientale (Sam.) Sam.

Ya-Li WangKey Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Department of Natural Products Chemistry, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China;College of Pharmacy, College (Institute) of Integrative Medicine, Dalian Medical University, Dalian, China
,
Jian-Chao ZhaoKey Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Department of Natural Products Chemistry, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China;College of Pharmacy, College (Institute) of Integrative Medicine, Dalian Medical University, Dalian, China
,
Jia-Hao LiangCollege of Pharmacy, College (Institute) of Integrative Medicine, Dalian Medical University, Dalian, China
,
Xiang-Ge TianCollege of Pharmacy, College (Institute) of Integrative Medicine, Dalian Medical University, Dalian, China
,
Xiao-Kui HuoCollege of Pharmacy, College (Institute) of Integrative Medicine, Dalian Medical University, Dalian, China
,
Lei FengCollege of Pharmacy, College (Institute) of Integrative Medicine, Dalian Medical University, Dalian, China
,
Jing NingCollege of Pharmacy, College (Institute) of Integrative Medicine, Dalian Medical University, Dalian, China
,
Chao WangCollege of Pharmacy, College (Institute) of Integrative Medicine, Dalian Medical University, Dalian, China
,
Bao-Jing ZhangCollege of Pharmacy, College (Institute) of Integrative Medicine, Dalian Medical University, Dalian, China
,
Gang ChenKey Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Department of Natural Products Chemistry, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, ChinaCorrespondence[email protected]
,
Ning LiKey Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Department of Natural Products Chemistry, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, ChinaCorrespondence[email protected]
&
Cheng-Peng SunCollege of Pharmacy, College (Institute) of Integrative Medicine, Dalian Medical University, Dalian, ChinaCorrespondence[email protected]
 show all
Pages 776-781 | Received 17 Oct 2017, Accepted 18 Nov 2017, Published online: 28 Nov 2017
 
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Abstract

A new protostane-type triterpenoid, 5β,29-dihydroxy alisol A (1) was isolated from Alisma plantago-aquatica subsp. orientale (Sam.) Sam. as well as 12-deoxyphorbol-13α-pentadecanoate (2). We first report the presence of compound 2 in the genus Alisma. Their structures were established on the basis of 1D and 2D NMR, and HRESIMS spectroscopic analyses. All the isolated compounds were assayed for their inhibitory effects against human carboxylesterase 2 (HCE-2). Compounds 1 and 2 displayed inhibitory activities against HCE-2 with IC50 values of 29.2 and 4.6 μM, respectively. The interaction mechanisms of HCE-2 with compounds 1 and 2 were investigated by molecular docking, respectively.

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Related Research Data

A bioactive new protostane-type triterpenoid from Alisma plantago-aquatica subsp. orientale (Sam.) Sam.
Source: Figshare

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