Nucleoside alkaloids with anti-platelet aggregation activity from the rhizomes of Ligusticum striatum

Abstract

Two new (1–2) and six known (3–8) nucleoside alkaloids were isolated from the rhizomes of Ligusticum striatum DC. Compounds 1 and 2 (liguadenosines A and B) were unusual N-10 substituted adenosine derivatives. Their structures were elucidated by extensive spectroscopic analyses and ECD calculation. Most of them significantly inhibited the abnormal increase in platelet aggregation induced by ADP at concentrations of 50 and 100 μM. Particularly, the inhibitory effect of 3 was equivalent to aspirin.

Keywords:

• Ligusticum striatum
• nucleoside
• alkaloids
• adenosine derivatives
• anti-platelet aggregation activity

Acknowledgements

This work was supported by the Program for Comprehensive Exploitation and Regional Development of Genuine Crude Drugs of Sichuan Province [grant number 2017ZY002], the Sichuan Science and Technology Support Program [grant number 2015SZ0031], the Outstanding Youth Science Foundation of Sichuan Province (grant number 2015JQO030), and the Special Plan for Basic Scientific Work [grant number 2015FY111500-140].