Agave fructans and oligofructose decrease oxidative stress in brain regions involved in learning and memory of overweight mice

Abstract

Obesity is currently a public health problem worldwide. Recently, non-reducing carbohydrates, that include β(2→1) and β(2→6) linkages in their structure, have been of particular interest in the field of obesity because they are involved in lipid metabolism. Some of these are agave fructans (AF) and oligofructose (OF). In this study, we evaluated both AF and OF on oxidative stress (OS) markers in the brain of overweight mice (OM). AF and OF decreased TBARS levels and carbonyls at different levels in hippocampus (HP), frontal cortex (FC) and cerebellum (CB) of OM. The results indicated that fructans may have anti-oxidative potential and can be used as an alternative treatment for the prevention of the consequences of this pathology.

Keywords:

• Fructans
• prebiotics
• overweight mice
• brain
• oxidative stress

Acknowledgments

We are grateful to Huazano-García A. for donating the brain organs from her in vivo experiment.