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Natural Product Research
Formerly Natural Product Letters
Volume 33, 2019 - Issue 11
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Research Articles

Steroids from herbs of Reineckia carnea and their anticomplement activities

Xu XuJiangxi University of Traditional Chinese Medicine, Nanchang, China
,
Bei WuNanchang Insitute for Food and Drug Control, Nanchang, PR China
,
Yanzhi ZhanJiangxi University of Traditional Chinese Medicine, Nanchang, China
,
Wenping HuangState Key Laboratory of Innovative Drug and Efficient Energy-Saving Pharmaceutical Equipment, Jiangxi University of Traditional Chinese Medicine, Nanchang, China
,
Shilin YangJiangxi University of Traditional Chinese Medicine, Nanchang, China;State Key Laboratory of Innovative Drug and Efficient Energy-Saving Pharmaceutical Equipment, Jiangxi University of Traditional Chinese Medicine, Nanchang, China
,
Quan WenJiangxi University of Traditional Chinese Medicine, Nanchang, ChinaCorrespondence[email protected]
&
Yulin FengJiangxi University of Traditional Chinese Medicine, Nanchang, China;State Key Laboratory of Innovative Drug and Efficient Energy-Saving Pharmaceutical Equipment, Jiangxi University of Traditional Chinese Medicine, Nanchang, ChinaCorrespondence[email protected]
 show all
Pages 1570-1576 | Received 09 Nov 2017, Accepted 26 Dec 2017, Published online: 15 Jan 2018
 
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Abstract

A new polyhydroxylated pregnane, named lβ,2β,3β,4β,5β,6β-hexolhydroxy-pregn-16-en-20-one (1), along with nine known (2–10) steroidal saponins were isolated from the whole plant of Reineckia carnea. Structure elucidations of all compounds were established by interpretation of their NMR spectral data, HR-ESI-MS and comparing with literatures. In addition, these compounds were evaluated with anticomplement activity. The result showed that compound 1 exhibited anticomplement effects with the CH50 values of 0.043 mg/mL, but saponins (2–10) showed no inhibition. Interestingly, hydrolysis of steroidal saponins (2–10) resulted in its aglycones (2a–10a) correspondingly which showed anticomplement activity with the CH50 values of 0.049–0.156 mg/mL.

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