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Natural Product Research
Formerly Natural Product Letters
Volume 33, 2019 - Issue 11
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Research Articles

New isolates from leaves of Nicotiana tabacum and their biological activities

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Pages 1577-1583 | Received 05 Aug 2017, Accepted 31 Dec 2017, Published online: 19 Jan 2018
 

Abstract

Three new isolates (13) including one new sterol and two new flavonoids together with three known sterols (46) were isolated from the leaves of Nicotiana tabacum. Their structures were determined mainly by spectroscopic methods, including extensive 1D and 2D NMR techniques. All compounds were evaluated for their anti-tobacco mosaic virus and cytotoxic activities. The results showed that compounds 2 and 3 exhibited high anti-TMV activity with inhibition rate of 34.2 and 33.4%, respectively, which were roughly equivalent to that of positive control. The cytotoxicities of compounds 1 and 46 against five human tumour cell lines were also tested, and tested compounds showed weak inhibitory activities against some tested human tumour cell lines.

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