Effect of Anacardium occidentale leaf extract on human acute lymphoblastic leukaemia cell lines

Abstract

Anacardium occidentale leaves are used in folk medicine due its therapeutic properties attributed to phenolic compounds. Therefore, this study was undertaken on its hydroethanolic leaf extract (AoHE) to evaluate cytotoxicity and apoptosis induction on acute lymphoblastic leukaemia cells. Results indicated that AoHE interfered in the cell cycle progression, inducing apoptosis by activation of casp3 at lower concentrations, thence, a promising candidate for the development of new cancer drugs.

Keywords:

• Cashew
• polyphenols
• apoptosis
• leukaemia cells

Disclosure statement

No potential conflict of interest was reported by the authors.

Funding

This work was supported by the CAPES/FAPITEC [grant number 08/2013] to JAL and MLHM; and FAPESP [grant number 12/12802] to JAY.