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Natural Product Research
Formerly Natural Product Letters
Volume 33, 2019 - Issue 11
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Review Article

New cytotoxic natural products from the mangrove biome: covering the period 2007–2015

Boris PejinDepartment of Life Sciences, Institute for Multidisciplinary Research – IMSI, University of Belgrade, Belgrade, SerbiaCorrespondence[email protected] [email protected]
&
Miodrag GlumacFood Oral Processing Laboratory, School of Food Science and Biotechnology – SFSB, Zhejiang Gongshang University, Hangzhou, People’s Republic of China
Pages 1624-1628 | Received 19 Nov 2017, Accepted 02 Jan 2018, Published online: 15 Jan 2018
 
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Abstract

Nowadays, the mangrove biome is considered to be a profound resource of natural products usually possessing cytotoxicity of a broader range. Covering the period 2007–2015, a total of 21 new naturally occurring compounds has stood out. For example, xylogranin B and swietephragmin C were found to exhibit very potent cytotoxic activity against the colon HCT-116 cells reaching IC50 values of 0.05 and 0.06 μM, respectively. Bearing in mind the efficacy of the majority compounds in the preliminary in vitro screens, these studies should be expanded to both ex vivo and in vivo screens including the evaluation of the relevant toxicological profiles.

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