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Natural Product Research
Formerly Natural Product Letters
Volume 33, 2019 - Issue 11
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Short Communication

Chemical constituents from the flowers of Satsuma mandarin and their free radical scavenging and α-glucosidase inhibitory activities

Anjana Adhikari-DevkotaGraduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan;Program for Leading Graduate Schools, Health Life Science: Interdisciplinary and Glocal Oriented (HIGO) Program, Kumamoto University, Kumamoto, JapanORCID Iconhttp://orcid.org/0000-0002-8173-6129
ORCID Icon,
Sara Mustafa Idris ElbashirGraduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
,
Takashi WatanabeGraduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
&
Hari Prasad DevkotaGraduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan;Program for Leading Graduate Schools, Health Life Science: Interdisciplinary and Glocal Oriented (HIGO) Program, Kumamoto University, Kumamoto, JapanCorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0002-0509-1621
ORCID Icon
Pages 1670-1673 | Received 21 Oct 2017, Accepted 02 Jan 2018, Published online: 15 Jan 2018
 
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Abstract

Flowers of Citrus plants are used as mild sedatives and for the treatment of insomnia in traditional medicines. In Japan, tea made from the flowers of Satsuma mandarin is consumed as healthy drink. Hesperidin (1), hesperetin (2), rutin (3), quercetin (4), nicotiflorin (5), eriocitrin (6), narirutin (7), phenylethyl glucoside (8) and unshuoside A (9) were isolated from the MeOH extract of fresh flowers. Structure elucidation of these compounds was performed on the basis of NMR spectroscopic data. Among them, rutin (3), quercetin (4) and eriocitrin (6) showed potent free radical scavenging activity, whereas hesperetin (2) and quercetin (4) showed potent α-glucosidase inhibitory activity.

Acknowledgements

We would like to thank Ms. Ukiko Murakami, Orange Blossom Co., Ltd., Kawachi, Kumamoto, Japan for providing the flowers of Satsuma mandarin.

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