Four new dammarane-type triterpenes derivatives from hydrolyzate of total Gynostemma pentaphyllum saponins and their bioactivities

Xiaoshu ZhangSchool of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China;Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China

Guohui ShiSchool of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China;Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China

Mingbing LiuSchool of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China;Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China

Rong ChenSchool of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China;Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China

Xiaojun WuSchool of Pharmacy, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China

Yuqing ZhaoSchool of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China;Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, People’s Republic of ChinaCorrespondence[email protected]

Abstract

Phytochemical investigation of hydrolysate of total G. pentaphyllum saponins led to the isolation of four novel triterpenes, Gypensapogenin U (1), Gypensapogenin V (2), Gypensapogenin W (3) and Gypensapogenin X (4). The structures of these compounds were identified by 1D, 2D-NMR and HR-ESI-MS evidences. Additionally, the protective activity of these new compounds against cardiomyocytes injury induced by H₂O₂ and their cytotoxic activity against t-HSC/Cl-6 cells were evaluated.

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Acknowledgements

We are glad to acknowledge the Analytical Center of Shenyang Pharmaceutical University for NMR measurements.

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Four new dammarane-type triterpenes derivatives from hydrolyzate of total Gynostemma pentaphyllum saponins and their bioactivities

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Four new dammarane-type triterpenes derivatives from hydrolyzate of total Gynostemma pentaphyllum saponins and their bioactivities

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