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Natural Product Research
Formerly Natural Product Letters
Volume 33, 2019 - Issue 11
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Research Articles

Chemical constituents and biological activities of Viburnum macrocephalum f. keteleeri

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Pages 1612-1616 | Received 24 Nov 2017, Accepted 10 Jan 2018, Published online: 25 Jan 2018
 

Abstract

Three new compounds (13) and seven known compounds (410) have been isolated from the ethanolic extract of Viburnum macrocephalum f. keteleeri using bioactivity-guided fractionation and identified as methyl (2-α-L-rhamnopyranosyloxy)acetate (1), methyl (2R-3-α-L-rhamnopyranosyloxy)glycerate (2), methyl (3R-4-α-L-rhamnopyranosyloxy-3-hydroxy)butanoate (3), bridelionoside B (4), (6S,7E,9R)-roseoside (5), linarionoside A (6), 3,7,11-trimethyl-1,6-dodecadien-3,10,11-triol (7), (+)-8-hydroxylinalool (8), β-sitosterol (9) and daucosterol (10). The structures of 13, including absolute configurations, were determined by spectroscopic data (1H and 13C NMR, HSQC, HMBC and ORD) and chemical methods. In addition, compounds 1–8 were assayed for their insecticidal and antimicrobial activities. Compounds 7 and 8 exhibited moderately insecticidal effects against Mythimna separata with LD50 values of 180 and 230 μg g−1, respectively. Compounds 2, 3, 7 and 8 showed varying antimicrobial activities with IC50 values ranging from 125 to 529 μM.

Acknowledgements

We are also grateful to the Analytical Detective Center, Yangzhou University, for recording MS and NMR spectra.

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