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Natural Product Research
Formerly Natural Product Letters
Volume 33, 2019 - Issue 12
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Short Communication

TLC-bioautography directed isolation of antibacterial compounds from active fractionation of Ferula ferulioides

Zhong-Lin SunSchool of Pharmacy, FudanUniversity, Shanghai, China
,
Tao LiuSchool of Pharmacy, FudanUniversity, Shanghai, China
,
Shuang-Ying WangSchool of Pharmacy, FudanUniversity, Shanghai, China
,
Xiao-Yue JiSchool of Chemistry and Chemical Engineering, Queen’s University Belfast, Belfast, UK
&
Qing MuSchool of Pharmacy, FudanUniversity, Shanghai, ChinaCorrespondence[email protected]
Pages 1761-1764 | Received 06 Sep 2017, Accepted 14 Jan 2018, Published online: 30 Jan 2018
 
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Abstract

A novel optimised isolation method, TLC-bioautography, was evaluated and utilised in this research. Antibacterial compounds which were isolated from the dichloromethane extract of Ferula ferulioides (Steud.) Korovin were detected by means of the method. Their structures were elucidated by extensive spectral and chemical methods. Their antibacterial activities against drug-resistant Staphylococcus aureus (S. aureus) strains were evaluated with broth microdilution method, and the results proved that TLC-bioautography was an effective and highly efficient way to screen natural compounds from plant extracts against drug-resistant strains.

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