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Natural Product Research
Formerly Natural Product Letters
Volume 33, 2019 - Issue 12
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Research Articles

Polygonatone H, a new homoisoflavanone with cytotoxicity from Polygonatum Cyrtonema Hua.

Wenxiang WangYunnan Agricultural University National & Local Joint Engineering Research Center on Gemplasm Utilization & Innovation of Chinese Medicinal Materials in Southwest China, Kunming, China
,
Xilatu DabuCollege of Resources and Environment, Yunnan Agricultural University, Kunming, China
,
Juan HeSchool of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, China
,
Huixiang YangSchool of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, China
,
Shengchao YangYunnan Agricultural University National & Local Joint Engineering Research Center on Gemplasm Utilization & Innovation of Chinese Medicinal Materials in Southwest China, Kunming, China
,
Junwen ChenYunnan Agricultural University National & Local Joint Engineering Research Center on Gemplasm Utilization & Innovation of Chinese Medicinal Materials in Southwest China, Kunming, China
,
Wei FanYunnan Agricultural University National & Local Joint Engineering Research Center on Gemplasm Utilization & Innovation of Chinese Medicinal Materials in Southwest China, Kunming, China;College of Resources and Environment, Yunnan Agricultural University, Kunming, China
,
Guanghui ZhangYunnan Agricultural University National & Local Joint Engineering Research Center on Gemplasm Utilization & Innovation of Chinese Medicinal Materials in Southwest China, Kunming, China
,
Jinlong CaiYunnan Agricultural University National & Local Joint Engineering Research Center on Gemplasm Utilization & Innovation of Chinese Medicinal Materials in Southwest China, Kunming, China
,
Honglian AiSchool of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, ChinaCorrespondence[email protected]
&
Meirong HaiYunnan Agricultural University National & Local Joint Engineering Research Center on Gemplasm Utilization & Innovation of Chinese Medicinal Materials in Southwest China, Kunming, ChinaCorrespondence[email protected]
 show all
Pages 1727-1733 | Received 26 Nov 2017, Accepted 21 Jan 2018, Published online: 19 Feb 2018
 
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Abstract

A new homoisoflavonoid, (3R)-5,7-dihydroxy-6-methyl-3-(2′-hydroxy-4′-methoxybenzyl)-chroman-4-one (1), namely polygonatone H, in addition to fourteen known homoisoflavones (2–15) were isolated from the rhizome of Polygonatum Cyrtonema Hua. The structures were identified with the aid of 1D/2D NMR spectroscopic technologies. Compounds 2, 6, 8, 10, 11, 13, and 15 were isolated from P. Cyrtonema for the first time. Compound 1 showed cytotoxicities to human cancer cell lines with IC50 values to comparable those of cisplatin.

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