Advanced search
Publication Cover
Natural Product Research
Formerly Natural Product Letters
Volume 33, 2019 - Issue 12
Submit an article Journal homepage
171
Views
12
CrossRef citations to date
0
Altmetric
Short Communication

A new coumarin from Juglans mandshurica Maxim induce apoptosis in hepatocarcinoma cells

Li-Li LouSchool of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China
,
Peng ZhaoSchool of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China
,
Zhuo-Yang ChengSchool of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China
,
Rui GuoSchool of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China
,
Guo-Dong YaoSchool of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China
,
Xiao-Bo WangChinese People’s Liberation Army 210 Hospital, Dalian, People’s Republic of China
,
Xiao-Xiao HuangSchool of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China;Chinese People’s Liberation Army 210 Hospital, Dalian, People’s Republic of ChinaCorrespondence[email protected]
&
Shao-Jiang SongSchool of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, People’s Republic of ChinaCorrespondence[email protected]
 show all
Pages 1791-1793 | Received 23 Dec 2017, Accepted 27 Jan 2018, Published online: 04 Feb 2018
 
Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days

Abstract

In this study, a new coumarin, juglansoside C (1) was isolated from the bark of Juglans mandshurica. Its chemical structure was identified by comprehensive spectroscopic analyses. The in vitro cytotoxicity assay showed that 1 exhibited moderate cytotoxicity against human hepatocellular carcinoma Hep3B cells with an IC50 value of 70.9 μM. Furthermore, Annexin V-FITC/PI staining assay indicated that 1 markedly induced apoptosis in Hep3B cells.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related Research Data

De novo assembly and characterization of the leaf, bud, and fruit transcriptome from the vulnerable tree Juglans mandshurica for the development of 20 new microsatellite markers using Illumina sequencing
Source: Springer Nature
Antitumor effects and immune regulation activities of a purified polysaccharide extracted from Juglan regia
Source: Elsevier BV
A new naphthalenone isolated from the green walnut husks ofJuglans mandshuricaMaxim.
Source: Informa UK Limited
JA, a new type of polyunsaturated fatty acid isolated from Juglans mandshurica Maxim, limits the survival and induces apoptosis of heptocarcinoma cells.
Source: Springer Science and Business Media LLC
One new 1,4-napthoquinone derivative from the roots of Juglans mandshurica
Source: Informa UK Limited
Alkaloids from Juglans Mandshurica maxim induce distinctive cell death in hepatocellular carcinoma cells.
Source: (:unav)
A new coumarin from Juglans mandshurica Maxim induce apoptosis in hepatocarcinoma cells
Source: Figshare
Two new diarylheptanoids isolated from the roots ofJuglans mandshurica
Source: Informa UK Limited
A new phenolic glycoside fromJuglans mandshurica
Source: Informa UK Limited
A new coumarin from Juglans mandshurica Maxim induce apoptosis in hepatocarcinoma cells
Source: Figshare
Two new cytotoxic glycosides isolated from the green walnut husks of Juglans mandshurica Maxim.
Source: Informa UK Limited
Hepatocellular carcinoma: From diagnosis to treatment.
Source: Elsevier BV
A new diarylheptanoid and a new diarylheptanoid glycoside isolated from the roots of Juglans mandshurica and their anti-inflammatory activities.
Source: (:unav)

Linking provided by 

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.