Advanced search
Publication Cover
Natural Product Research
Formerly Natural Product Letters
Volume 33, 2019 - Issue 12
Submit an article Journal homepage
335
Views
9
CrossRef citations to date
0
Altmetric
Short Communication

Acetylcholinesterase inhibitory active metabolites from the endophytic fungus Colletotrichum sp. YMF432

Zhe LiState Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University, Kunming, China;State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China
,
Ni MaState Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University, Kunming, China;State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China
&
Pei-Ji ZhaoState Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University, Kunming, China;State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, ChinaCorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0003-4612-1257
ORCID Icon
Pages 1794-1797 | Received 19 Dec 2017, Accepted 21 Jan 2018, Published online: 04 Feb 2018
 
Sample our Physical Sciences journals, sign in here to start your FREE access for 14 days

Abstract

An endophytic fungus, Chaetomium sp. YMF432, was isolated from Huperzia serrata (Thunb. ex Murray) Trev. and subjected to phytochemical investigation based on its special environment. From the extracts of fermentation solid of strain YMF 432, eight compounds including 1-O-methylemodin (1), 5-methoxy-2-methyl-3-tricosyl-1,4-benzoquinone (2), 4,8-dihydroxy-1-tetralone (3), (3β,5α,6α, 22E)-3-hydroxy-5,6-epoxy-7-one-8(14),22-dien-ergosta (4), ergosta-4,6,8(14),22-tetraen-3-one (5), β-sitostenone (6), β-sitosterol (7) and (22E,24R)-ergosta-5,7,22 -trien-3β-ol (8) were obtained. Their structures were elucidated on the basis of their spectroscopic data. These compounds were evaluated for acetylcholinesterase inhibitory activities in vitro. Compounds 1, 2, and 4 showed moderate acetylcholinesterase inhibitory activities (IC50 from 37.7 ± 1.5 to 370.0 ± 2.9 μM).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related Research Data

FUNGAL ENDOPHYTES: A Continuum of Interactions with Host Plants
Source: Annual Reviews
Antitumor sterols from the mycelia of Cordyceps sinensis
Source: Elsevier BV
Identification of C-24 alkyl epimers of marine sterols by 13 C nuclear magnetic resonance spectroscopy
Source: Canadian Science Publishing
Endophyte Fungal Isolates fromPodophyllumpeltatumProduce Podophyllotoxin
Source: American Chemical Society (ACS)
Six Immunosuppressive Features from an Ascomycete, Zopfiella longicaudata, Found in a Screening Study Monitored by Immunomodulatory Activity
Source: Pharmaceutical Society of Japan
Neobulgarones A-F from Cultures of Neobulgaria pura, New Inhibitors of Appressorium Formation of Magnaporthe grisea.
Source: Japan Antibiotics Research Association
Natural products from endophytic microorganisms.
Source: American Chemical Society (ACS)
A new and rapid colorimetric determination of acetylcholinesterase activity.
Source: Elsevier BV
Microbial ecology of leaves
Source: Springer New York
Dihydroisocoumarins and a tetralone from Cytospora eucalypticola
Source: Elsevier BV
Progress in Clinical, Pharmacological, Chemical and Structural Biological Studies of Huperzine A: A Drug of Traditional Chinese Medicine Origin for the Treatment of Alzheimers Disease
Source: Bentham Science Publishers Ltd.
Bioactive anthraquinones from endophytic fungus Aspergillus versicolor isolated from red sea algae
Source: Springer Nature
An Endophytic Fungus fromNothapodytesfoetidathat Produces Camptothecin
Source: American Chemical Society (ACS)
Bioactive Metabolites from Spilanthes acmella Murr.
Source: MDPI AG
Cytotoxic ergosterols frompaecilomyces sp. J300
Source: Springer Nature
Helvetica Chimica Acta
Source: Wiley
Acetylcholinesterase inhibitory active metabolites from the endophytic fungus Colletotrichum sp. YMF432
Source: Figshare
Fungal endophytes from higher plants: a prolific source of phytochemicals and other bioactive natural products
Source: Springer Science and Business Media LLC
Acetylcholinesterase inhibitory active metabolites from the endophytic fungus Colletotrichum sp. YMF432
Source: Figshare
Leishmanicidal, trypanocidal, and cytotoxic activities of endophytic fungi associated with bioactive plants in Brazil
Source: FapUNIFESP (SciELO)

Linking provided by 

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.