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Natural Product Research
Formerly Natural Product Letters
Volume 33, 2019 - Issue 12
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Research Articles

Diterpenoid alkaloids from Aconitum brevicalcaratum as autophagy inducers

Haiyue JiangSchool of Life Science and Engineering, Southwest Jiaotong University, Chengdu, P.R. China
,
Shuai HuangSchool of Life Science and Engineering, Southwest Jiaotong University, Chengdu, P.R. China;Center for Molecular and Translational Medicine, Institute of Biomedical Sciences, Georgia State University, Atlanta, GA, USA
,
Feng GaoSchool of Life Science and Engineering, Southwest Jiaotong University, Chengdu, P.R. China
,
Yongqi ZhenSchool of Life Science and Engineering, Southwest Jiaotong University, Chengdu, P.R. China
,
Chunying LiCenter for Molecular and Translational Medicine, Institute of Biomedical Sciences, Georgia State University, Atlanta, GA, USA
&
Xianli ZhouSchool of Life Science and Engineering, Southwest Jiaotong University, Chengdu, P.R. ChinaCorrespondence[email protected]
Pages 1741-1746 | Received 13 Dec 2017, Accepted 02 Feb 2018, Published online: 12 Feb 2018
 
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Abstract

A new C19 diterpenoid alkaloid, brevicanine (1) and six known ones (2–7) were isolated from Aconitum brevicalcaratum (Finet et Gagnep.) Diels. Their structures were elucidated on the basis of extensive spectroscopic analyses. The cytotoxicity of those compounds was investigated against HCT116 human cancer cell line, which showed none of them possessing considerable anti-proliferative activities. To evaluate the autophagy effect of compounds 1–7, Western blot was used to detect the expression of autophagic marker by stimulating human cancer HCT116 cells. The results showed that compound 6 induced protective autophagy in HCT116 cells. Mechanistic insight showed that compound 6 induced protective autophagy through p53 activation, ERK1/2 and p38 MAPK signaling cascade.

Acknowledgement

The authors are grateful to Xiao–qing Gan, Yu–ning Hou, Xiao–nan Sun and Yu Zhou for technical assistance.

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