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Natural Product Research
Formerly Natural Product Letters
Volume 33, 2019 - Issue 3
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Research Articles

Chemical constituents of Silene montbretiana

Hilal KılınçFaculty of Engineering, Department of Geological Engineering, Dokuz Eylül University, Buca, İzmir, Turkey;Faculty of Science, Department of Chemistry, Ege University, Bornova, İzmir, Turkey
,
Milena MasulloDepartment of Pharmacy, University of Salerno, Fisciano, ItalyCorrespondence[email protected]
,
Alfredo BottoneDepartment of Pharmacy, University of Salerno, Fisciano, Italy
,
Tamer KarayıldırımFaculty of Science, Department of Chemistry, Ege University, Bornova, İzmir, TurkeyORCID Iconhttps://orcid.org/0000-0001-7451-0810
ORCID Icon,
Özgen AlankuşFaculty of Science, Department of Chemistry, Ege University, Bornova, İzmir, Turkey
&
Sonia PiacenteDepartment of Pharmacy, University of Salerno, Fisciano, Italy
Pages 335-339 | Received 08 Feb 2018, Accepted 05 Mar 2018, Published online: 21 Mar 2018
 
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Abstract

A new steroidal glycoside, 3-O-β-d-glucopyranosyl-3β,25-dihydroxy-5β-cholest-7-en-6-one 25-O-β-d-glucopyranoside (1), together with six known steroidal derivatives (2-7), one cerebroside (8) and one flavonoid (9) were isolated from Silene montbretiana Boiss (Caryophyllaceae), a perennial herb growing mainly in the Middle and East Anatolia, Azerbaijan, Iran, and Turkey. Their structures were established by the extensive use of 1D and 2D NMR experiments along with ESI-MS analyses. The cytotoxicity against the cancer A549 (human alveolar basal carcinoma) and Hela (human epitheloid cervix carcinoma) cell lines has been evaluated. None of the tested compounds, in a range of concentrations between 12.5 and 100 μM, caused a significant reduction of the cell number.

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