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Natural Product Research
Formerly Natural Product Letters
Volume 33, 2019 - Issue 3
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Research Articles

Two new polyketides from the fungus Penicillium oxalicum MHZ153

Yi RenModern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, People’s Republic of China
,
Ling-Hui ChaoModern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, People’s Republic of China
,
Jing SunModern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, People’s Republic of China
,
Xiao-Nan ChenModern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, People’s Republic of China
,
Hui-Na YaoModern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, People’s Republic of China
,
Zhi-Xiang ZhuModern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, People’s Republic of China
,
Dan DongInstitute of Plant and Environment Protection, Beijing Academy of Agriculture and Forestry Sciences, Beijing, People’s Republic of China
,
Ting LiuInstitute of Plant and Environment Protection, Beijing Academy of Agriculture and Forestry Sciences, Beijing, People’s Republic of China
,
Peng-Fei TuModern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, People’s Republic of China
&
Jun LiModern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, People’s Republic of ChinaCorrespondence[email protected]
 show all
Pages 347-353 | Received 12 Dec 2017, Accepted 10 Mar 2018, Published online: 20 Mar 2018
 
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Abstract

Two new polyketides, penicilloxalones A (1) and B (2), together with 13 known compounds (3–15), were isolated from the ethyl acetate extract of the solid substrate fermentation cultures of the fungus Penicillium oxalicum MHZ153. The structures of the isolates were determined by spectroscopic analysis and comparison of their spectroscopic and physicochemical data with the literature values. Compounds 7 and 11 showed inhibition of nitric oxide production in lipopolysaccharide-stimulated BV-2 microglial cells with IC50 values of 0.9 ± 0.2 μM and 87.9 ± 0.7 μM, respectively.

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