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Natural Product Research
Formerly Natural Product Letters
Volume 33, 2019 - Issue 3
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Research Articles

Two new phenylspirodrimanes from the deep-sea derived fungus Stachybotrys sp. MCCC 3A00409

Xin-hua MaFujian Provincial Key Laboratory of Pharmacology of Natural Medicine, School of Pharmacy, Fujian Medical University, Fuzhou, P.R. China
,
Wei-min ZhengFujian Provincial Key Laboratory of Pharmacology of Natural Medicine, School of Pharmacy, Fujian Medical University, Fuzhou, P.R. China
,
Kai-hui SunFujian Provincial Key Laboratory of Pharmacology of Natural Medicine, School of Pharmacy, Fujian Medical University, Fuzhou, P.R. China
,
Xiao-fan GuFujian Provincial Key Laboratory of Pharmacology of Natural Medicine, School of Pharmacy, Fujian Medical University, Fuzhou, P.R. China
,
Xian-ming ZengFujian Provincial Key Laboratory of Pharmacology of Natural Medicine, School of Pharmacy, Fujian Medical University, Fuzhou, P.R. China
,
Hai-tao ZhangFujian Provincial Key Laboratory of Pharmacology of Natural Medicine, School of Pharmacy, Fujian Medical University, Fuzhou, P.R. China
,
Tian-hua ZhongKey Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, State Oceanic Administration, Xiamen, P.R. China
,
Zong-ze ShaoKey Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, State Oceanic Administration, Xiamen, P.R. China
&
Yong-hong ZhangFujian Provincial Key Laboratory of Pharmacology of Natural Medicine, School of Pharmacy, Fujian Medical University, Fuzhou, P.R. ChinaCorrespondence[email protected] [email protected]
 show all
Pages 386-392 | Received 20 Oct 2017, Accepted 17 Mar 2018, Published online: 23 Mar 2018
 
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Abstract

Two new phenylspirodrimanes, stachybotrin H (1) and stachybotrysin H (9) together with eleven known analogues (2–8, 10–13) were isolated from deep-sea derived Stachybotrys sp. MCCC 3A00409. Their structures were determined by extensive NMR data and mass spectroscopic analysis. Compounds 9–12 showed weak cytotoxicity against three human cancer cell lines K562, Hela and HL60 with IC50 in the range of 18.5–52.8 μM.

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