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Natural Product Research
Formerly Natural Product Letters
Volume 33, 2019 - Issue 8
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Research Articles

Four new phenolic constituents from the rhizomes of Gastrodia elata Blume

, , , , , , & show all
Pages 1140-1146 | Received 07 Feb 2018, Accepted 01 Apr 2018, Published online: 20 Apr 2018
 

Abstract

Four new gastrodin derivatives containing a trans-cinnamoyl unit (1–4) and nine known compounds (5–13) were isolated from the rhizomes of Gastrodia elata Blume. All these compounds were evaluated for their neuroprotective effects against 6-hydroxydopamine-induced cell death, and compounds 7 and 12 showed potent activities with EC50 values of 10.5 and 10.2 μM, respectively.

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