Structurally diverse diterpenoids from Trigonostemon howii

Yan-Ping LiuKey Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, P. R. China;Key Laboratory of Southern Medicinal Plants Resources of Haikou City, Hainan Normal University, Haikou, P. R. China

Qing WenKey Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, P. R. China;Key Laboratory of Southern Medicinal Plants Resources of Haikou City, Hainan Normal University, Haikou, P. R. China;College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, P. R. China

Shi HuKey Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, P. R. China;Key Laboratory of Southern Medicinal Plants Resources of Haikou City, Hainan Normal University, Haikou, P. R. China;College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, P. R. China

Yan-Lei MaKey Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, P. R. China;Key Laboratory of Southern Medicinal Plants Resources of Haikou City, Hainan Normal University, Haikou, P. R. China;College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, P. R. China

Zhi-Hua JiangKey Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, P. R. China;Key Laboratory of Southern Medicinal Plants Resources of Haikou City, Hainan Normal University, Haikou, P. R. China;College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, P. R. China

Jin-Ying TangKey Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, P. R. China;Key Laboratory of Southern Medicinal Plants Resources of Haikou City, Hainan Normal University, Haikou, P. R. China;College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, P. R. China

Yan-Hui FuKey Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, P. R. China;Key Laboratory of Southern Medicinal Plants Resources of Haikou City, Hainan Normal University, Haikou, P. R. China;College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, P. R. ChinaCorrespondence[email protected]

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Abstract

Phytochemical investigation on the stems and leaves of Trigonostemon howii resulted in the isolation of a new abietane diterpenoid, trigohowimine A (1), along with seven known structurally diverse diterpenoids (2–8). The structure of 1 was elucidated by extensive spectroscopic methods and the known compounds were identified by comparison with data reported in the literature. New compound 1 was evaluated for its cytotoxicities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480. Compound 1 showed significant inhibitory effects against various human cancer cell lines with IC₅₀ values ranging from 0.82 to 8.53 μM.

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Structurally diverse diterpenoids from Trigonostemon howii

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Structurally diverse diterpenoids from Trigonostemon howii

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