Discovery of a new biphenyl derivative by epigenetic manipulation of marine-derived fungus Aspergillus versicolor

Jing Xuan ZhuLi Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Ningbo University, Ningbo, China

Lijian DingLi Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Ningbo University, Ningbo, China;Key Laboratory of Marine Biotechnology of Zhejiang Province, Ningbo University, Ningbo, ChinaCorrespondence[email protected]

http://orcid.org/0000-0002-2259-9830

Shan HeLi Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Ningbo University, Ningbo, China;Key Laboratory of Marine Biotechnology of Zhejiang Province, Ningbo University, Ningbo, ChinaCorrespondence[email protected]

Abstract

Cultivation of the marine-derived Aspergillus versicolor MCCC 3A00080 with the addition of a histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), significantly enhanced the diversity of secondary metabolites. From the culture treated, a new biphenyl derivative, named versiperol A (1), along with two known compounds, 2,4-dimethoxyphenol (2) and diorcinol (3) were isolated. The structures of 1–3 were established based on spectroscopic analysis and comparison with literature data. Among the isolates, versiperol A (1) exhibited modest inhibition of Staphylococcus aureus growth with MIC value of 8 μg/mL.

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Discovery of a new biphenyl derivative by epigenetic manipulation of marine-derived fungus Aspergillus versicolor

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Discovery of a new biphenyl derivative by epigenetic manipulation of marine-derived fungus Aspergillus versicolor

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