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Natural Product Research
Formerly Natural Product Letters
Volume 33, 2019 - Issue 22
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Research Articles

Antimicrobial and cytotoxic juglones from the immature exocarps of Juglans mandshurica

Qin YangThe Key Laboratory of Traditional Chinese Medicine Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine, School of Pharmacy, Binzhou Medical University, Yantai, China
,
Qing-Shou YaoCollege of Life Sciences, Shandong Agricultural University, Taian, China
,
Yi KuangZhejiang Provincial Collaborative Innovation Center for Bamboo Resources and High-efficiency Utilization, Zhejiang A&F University, Lin’an, China
,
Yue-Zhi ZhangThe Key Laboratory of Traditional Chinese Medicine Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine, School of Pharmacy, Binzhou Medical University, Yantai, China
,
Ling-Ling FengThe Key Laboratory of Traditional Chinese Medicine Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine, School of Pharmacy, Binzhou Medical University, Yantai, China
,
Lu ZhangThe Key Laboratory of Traditional Chinese Medicine Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine, School of Pharmacy, Binzhou Medical University, Yantai, China
,
Lin GuoThe Key Laboratory of Traditional Chinese Medicine Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine, School of Pharmacy, Binzhou Medical University, Yantai, China
,
Ze-Ping XieThe Key Laboratory of Traditional Chinese Medicine Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine, School of Pharmacy, Binzhou Medical University, Yantai, ChinaCorrespondence[email protected]
&
Shu-Min ZhangThe Key Laboratory of Traditional Chinese Medicine Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine, School of Pharmacy, Binzhou Medical University, Yantai, ChinaCorrespondence[email protected]
 show all
Pages 3203-3209 | Received 19 Jan 2018, Accepted 19 Apr 2018, Published online: 04 May 2018
 
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Abstract

Juglonols A−C (1−3), three new juglone derivatives possessing a hydroxyethyl side chain, were isolated from an organic extract of the immature exocarps of Juglans mandshurica together with five known tetralones (4–8). Their structures were elucidated by extensive spectroscopic analyses and comparison with literature data. The new juglone derivatives exhibited inhibitory activities towards a panel of bacteria and fungi, as well as cancer cell lines. In contrast, the known tetralone homologues (4−8) appeared to be much less efficacy.

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