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Natural Product Research
Formerly Natural Product Letters
Volume 33, 2019 - Issue 24
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Research Articles

Synthesis and biological evaluation of C-13, C-14 modified taxane analogues from 1-deoxybaccatin VI

Ping Tang Department of Chemistry, Innovative Drug Research Center, College of Sciences, Shanghai University , Shanghai, China
,
Hai-Xia Lin Department of Chemistry, Innovative Drug Research Center, College of Sciences, Shanghai University , Shanghai, ChinaCorrespondence[email protected]
,
Tian-Hai Yuan Department of Chemistry, Innovative Drug Research Center, College of Sciences, Shanghai University , Shanghai, China
&
Yong-Mei Cui Department of Chemistry, Innovative Drug Research Center, College of Sciences, Shanghai University , Shanghai, ChinaCorrespondence[email protected]
Pages 3478-3484 | Received 01 Feb 2018, Accepted 31 May 2018, Published online: 13 Jun 2018
 
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Abstract

Four C-13, C-14 side chain modified 9(R)-hydroxy-1-deoxy-taxane analogues 15, 16, 19 and 22 were semi-synthesized from 1-deoxybaccatin VI. The in vitro antitumor activity of these compounds was evaluated against A549 and A2780 cell lines. The preliminary SAR analysis showed that introduction of oxygen-containing group on C-14 could improve the cytotoxic activities.

Acknowledgments

The authors thank Drs. H. Deng and M. Shao, The Instrumental Analysis& Research Center of Shanghai University, for structural analysis.

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