An indole diterpenoid isolated from the fungus Drechmeria sp. and its antimicrobial activity

Abstract

One new indole diterpenoid, drechmerin I (1), was isolated from the fermentation broth of Drechmeria sp. isolated from the root of Panax notoginseng. Its structure was elucidated based on 1 D and 2 D nuclear magnetic resonance (NMR), high resolution electrospray ionization mass spectrum (HRESIMS), and electronic circular dichroism (ECD) spectroscopic analyses as well as TD DFT calculations of ECD spectra. Drechmerin I (1) was assayed for its antimicrobial activity against Candida albicans, Staphylococcus aureus, Bacillus cereus, B. subtillis, Pseudomonas aeruginosa, and Klebsiella pneumonia, respectively. Drechmerin I (1) showed antimicrobial activities against B. subtillis with an MIC value of 200 μg/mL. The interaction of S. aureus peptide deformylase with drechmerin I (1) was investigated by molecular docking.

Graphical Abstract

Keywords:

• Drechmeria sp.
• indole diterpenoid
• antimicrobial activity
• molecular docking

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This research was supported by National Natural Science Foundation of China (No. 81703679, 81703397, and 81622047), the Major Science and Technique Program in Yunnan Province (2016ZF001-001, 2017IB038), Yung-Chi Cheng academician workstation of Yunnan provincial academy of science and technology (2015IC017), National Science and Technology Major Project (2017ZX09305001-002), Distinguished professor of Liaoning Province, and Innovation Team of Dalian Medical University, and Natural Science Foundation of Institute of Integrative Medicine, Dalian Medical University (ICIM2017001).