Chemical constituents from the leaves of Melia azedarach

Abstract

Six compounds, benzyl 3-O-β-D-glucopyranosyl-7-hydroxybenzoate (1), spathulenol (2), 1,7,8-trihydroxy-2-naphtaldehyde (3), quercetin (4), astragalin (5) and 2-methoxy-4-(2-propenyl)phenyl β-D-glucoside (6), were isolated from the leaves of Melia azedarach L. The structure elucidation of compound 1 was discussed in detail based on its 2D-NMR data. Compound 1 showed weak cytotoxicity against the cell lines of T-24, NCI-H460, HepG2, SMMC-7721, CNE, MDA-MB-231 and B16F10 with the inhibition rates from 10.01% to 34.05% at the concentration of 80 μM.

Keywords:

• Melia azedarach L.
• benzyl 3-O-β-D-glucopyranosyl-7-hydroxybenzoate
• cytotoxicity

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by the National Natural Science Foundation of China under Grant 81360477; Natural Science Foundation of Guangxi under Grant 2016GXNSFAA380268 and 2016GXNSFAA380041; and Guangxi BaGui Scholars Fund under Grant [2017]143. This fund was issued by the Sciences and Technology Department of Guangxi Province, which was similar with “The Thousand Talents Plan” initiated by Chinese government. Another work (doi:10.3390/molecules23010121) completed by our colleagues was also supported by this fund.