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Abstract
A new aporphine glycoside, (-)-anolobine-9-O-β-D-glucopyranoside was isolated from the twigs of pawpaw (Asimina triloba) along with 7 known alkaloids including five aporphine alkaloids (anolobine, nornuciferine, norushinsunine, liriodenine, and lysicamine), a proaporhine alkaloid (stepharine), and a tetrahydrobenzylisoquinoline alkaloid (coclaurine). Among these compounds, nornuciferine, lysicamine, stepharine, and coclaurine are reported for the first time from this plant. The structure of the new compound was elucidated by spectroscopic methods, including 1 D, 2 D NMR, and HRESI-MS. The absolute configuration of compounds 1, 2, 7 and 8 was determined by CD experiment.
Graphical Abstract
Acknowledgements
This work was supported by the Food and Drug Administration “Science Based Authentication of Dietary Supplements” [grant number 2U01FD004246-06]. FDA Disclaimer: The findings and conclusions in this report are those of the authors only and do not represent FDA positions or policies. Author (TM) is thankful to King Khalid University, Abha, Saudia Arabia for financial support. Authors are also appreciative to Dr. V. Raman for providing plant picture and Dr. B. Avula for help in HRESIMS analysis.
Disclosure statement
No potential conflict of interest was reported by the authors.
