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Abstract
Two new lignans mubezhisol (1) and mubezhisal (2), together with twenty six known compounds (3–28) were isolated from water-soluble fraction from the semens of Momordica cochinchinensis. In the subsequent action evaluation, four saponins (4, 6, 13, 27), six lignans (1, 2, 16, 17, 22, 23), and one naphthoquinone (24) exhibited the significant cytotoxicity. The results indicated that various saponins and lignans were mainly responsible for the antitumor activities of Momordicae Semen.
GRAPHICAL ABSTRACT
Acknowledgment
The authors are really grateful to Dr. Bona Dai of the Instrumental Analysis Center of Shanghai Jiao Tong University, for the measurements of NMR.
Disclosure statement
No potential conflict of interest was reported by authors.
Additional information
Funding
This study was financially supported by a grant of National Natural Science Foundation of China (No. 81374067).
