Two new xanthone glycosides from Swertia punicea Hemsl. and their anti-inflammatory activity

Abstract

Two new xanthone glycosides (1–2), together with seven known analogues (3–9), were isolated from whole herb of Swertia punicea. The structures of these metabolites were established on the basis of detailed spectroscopic analysis and comparison with data reported in the literature. In an in vitro test, all isolates were evaluated for their anti-inflammatory activity. The results revealed that all of them showed significant anti-inflammatory activity with IC₅₀ values ranging from 1.237 to 3.319 mM. Compounds 3, 4, and 5 (IC₅₀ values in the range 1.237–1.987 mM) displayed more potent anti-inflammatory activity than the positive control, indomethacin (IC₅₀ value of 2.004 mM).

Graphical Abstract

Keywords:

• Swertia punicea
• xanthone glycosides
• anti-inflammatory activity

Additional information

Funding

This work was financially supported by Technology Center, China Tobacco Yunnan Industrial Co., Ltd [grant number JSZX20151008-52].