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Natural Product Research
Formerly Natural Product Letters
Volume 33, 2019 - Issue 20
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Research Articles

Microbial transformation of isocoronarin D by Cunninghamella echinulata NRRL 1386

Ratchanaporn ChokchaisiriDepartment of Chemistry, School of Science, University of Phayao, Muang, Phayao, Thailand; Correspondence[email protected]
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,
Waraluck ChaichompooDepartment of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok, Thailand; View further author information
,
Oratai SukcharoenDepartment of Biotechnology, Faculty of Science, Ramkhamhaeng University, Bangkok, ThailandView further author information
,
Apichart SuksamrarnDepartment of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok, Thailand; View further author information
&
Lucksagoon GanranooDepartment of Chemistry, School of Science, University of Phayao, Muang, Phayao, Thailand; View further author information
Pages 2890-2896 | Received 23 May 2018, Accepted 03 Aug 2018, Published online: 20 Nov 2018
 
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Abstract

The diterpene isocoronarin D (1) is a bioactive major constituent of labdane diterpene from the aerial parts of Curcuma comosa Roxb. (Zingiberaceae), the Thai medicinal plant. Microbial transformation of 1 was performed by the fungus Cunninghamella echinulata NRRL 1386 to yield three new metabolites, 3β-hydroxyisocoronarin D (2), 6α-hydroxyisocoronarin D (3) and 3β,7α-dihydroxyisocoronarin D (4). The structures of the new compounds were elucidated by spectroscopic techniques.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by The Thailand Research Fund (grant no. DBG5980003) and the Center of Excellence for Innovation in Chemistry (PERCH-CIC), and Office of the Higher Education Commission.

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