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Abstract
Three new labdane-type diterpenoids, callicapene M3-M5 (1–3) were isolated from the Callicarpa macrophylla Vahl. Their structures were identified by spectroscopic method. The isolated compounds were evaluated for inhibitory activity on NO production in LPS-activated RAW 264.7 macrophage cells by using MTT assays. Compounds 1–3 showed potent inhibitory activity, with IC50 value of 48.15, 46.31 and 38.72 μM respectively.
GRAPHIC ABSTRACT
Acknowledgments
We thank for Mr. Zi-Shuang Liu of analysis & testing centers of Innotech Technology (Dalian) Co., Ltd. for the NMR data measurements. We also thank Professor Jincai Lu for identification of the plant material.
Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
This work was financially supported by 2016 Young Backbone Teacher Project of Henan Polytechnic University (2016XQG-17), Doctoral fund project of Henan Polytechnic University (B2014-068), 2018 Henan province science and technology breakthrough project (182102310680), Henan province higher education teaching reform research and practice project (2017SJGLX262) and 2017 education teaching reform research and practice project of Henan Polytechnic University (2017JG036).
