Benzophenanthridine alkaloids from the roots of Thalictrum microgynum Lecoy.ex Oliv

Abstract

A new benzophenanthridine alkaloid, 2,3,9-trimethoxy-7,8-methylenedioxy-5-methylbenzo[c]-6(5H) phenanthridone (2) and a benzophenanthridine alkaloid first found from natural sources, 2,3-dimethoxy-7,8- methylenedioxy-5-methylbenzo[c]-6(5H)- phenanthridone (1) together with two known benzophenanthridine alkaloids, Dihydrosanguinarine (3) and Dihydrochelilutine (4) were isolated from the roots of Thalictrum microgynum Lecoy.ex Oliv. The structures of 1 and 2 were elucidated using various spectroscopic techniques including HRESIMS and 1 D and 2 D NMR. Antibacterial activity of these compounds were tested. Compound 1, 3 and 4 showed antibacterial activity against Staphylococcus aureus with MIC values of 50, 100, 25 μg/mL, respectively.

Graphical Abstract

Keywords:

• Buttercup family
• Thalictrum genus
• Thalictrum microgynum Lecoy.ex Oliv
• benzophenanthridine alkaloid

Disclosure statement

The authors declare no competing financial interests.

Figure 1. Structures of compounds 1–4.

Additional information

Funding

This work was supported by the National Natural Science Foundation of China under Grant number 31670351.