Two new polyketides isolated from a diethyl sulphate mutant of marine-derived Penicillium purpurogenum G59

Abstract

Two new polyketides, purpurofuranone (1) and purpuropyranone (2), were isolated along with the known polyketides, cillifuranone (3) and taiwapyrone (4), from a mutant BD-3n-1 derived from the diethyl sulfate (DES) mutagenesis of a marine-derived Penicillium purpurogenum G59. The structures of 1 and 2 were elucidated by spectroscopic methods especially on the basis of X-ray diffraction and calculated optical rotations data. The plausible biosynthesis of 1 − 4 was also proposed and discussed. In preliminary MTT assay, 1 − 4 showed no notable inhibitory effects on the tested four human cancer cell lines.

Graphical Abstract

Keywords:

• Purpurofuranone
• purpuropyranone
• polyketides
• Penicillium purpurogenum
• diethyl sulfate (DES) mutagenesis

Supplementary materials

The experimental, NMR data of 1 and 2, and the original NMR spectra of 1and 2 are available in the supplementary Materials.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by the grants from the NSFC (grant number 81573300), China.