Abstract
A new indole diterpene, named penicindopene A (1), together with seven known compounds (2 – 8), was isolated from the deep-sea fungus Penicillium sp. YPCMAC1. The structure of penicindopene A was elucidated by extensive spectroscopic analyses (1 D and 2 D NMR, and HRESIMS data), in addition to the ECD calculations for the assignments of its absolute configuration. Penicindopene A represented the first example of indole diterpenes possessing a 3-hydroxyl-2-indolone moiety, and it exhibited moderate cytotoxicities against A549 and HeLa cell lines with IC50 values of 15.2 and 20.5 µM, respectively.
Graphical Abstract
![](/cms/asset/743aaf42-cd59-4161-965c-14321cfd2b60/gnpl_a_1514402_uf0001_c.jpg)
Supplementary material
Supplementary material relating to this article is available online. The NMR spectra, HRESIMS spectrum, and the theoretical calculation details of ECD spectra of 1 are included.
Acknowledgements
We thank Dr. Wei Li in Sun Yat-Sen University for ECD calculations.
Disclosure statement
No potential conflict of interest was reported by the authors.